GLIOFORCE Targeting Cellular Biomechanics to block Tumour Cell Invasion

Duration:
01.08.2026–31.07.2030

GLIOFORCE will investigate how biophysical forces contribute to the spread of invasive cancer. By integrating state-of-art in vivo 3-photon imaging and quantum biosensors with in silico biomechanics
modelling and computational drug design, GLIOFORCE aims to identify and target cancer-specific biomechanical vulnerabilities to block invasion and ultimately improve patient outcomes.

Contact

Primary objective:

To build a strong and lasting interdisciplinary framework that describes, models, and targets biomechanical forces during cancer cell invasion.

Secondary objectives:

  • Integrate advanced imaging, genetics and biomechanics to measure and manipulate cancer invasion.
  • Develop predictive in silico models for cancer cell invasion incorporating biomechanical parameters.
  • Explore advanced quantum emitters as innovative reporters of biomechanical forces.
  • Design and test new chemical compounds targeting cancer-specific biomechanical vulnerabilities.
  • Build lasting bridges between biomedicine, physics, engineering and pharmacy environments.
  • Raise awareness amongst clinicians and pathologists, incorporate biomechanics elements in curricula for students, and in advanced courses to train the next generation of scientists.

Participants

Funding

GLIOFORCE is financed by UiO:Life Science

Published Nov. 5, 2025 8:33 AM - Last modified Nov. 5, 2025 8:33 AM